# 2023 HIV-1 latency modulators |
HIV-1 latency modulators aims to develop therapies targeting latent HIV-infected CD4+ T cells, which traditional treatments overlook. These cells house proviruses capable of reactivation. The "shock-and-kill" approach employs latency-reversing agents (LRAs) to activate these proviruses, enabling elimination via the host's immune response. This research identifies the plant Croton oligandrus as a potent antiviral. Extracts from this plant demonstrated latency-reversing potential and might serve as foundation materials for new HIV/AIDS cures.
Iscte – University Institute of Lisbon
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