HIV-1 latency modulators


Croton Oligandrus extracts for new latent HIV cell therapy

HIV-1 latency modulators aims to develop therapies targeting latent HIV-infected CD4+ T cells, which traditional treatments overlook. These cells house proviruses capable of reactivation. The "shock-and-kill" approach employs latency-reversing agents (LRAs) to activate these proviruses, enabling elimination via the host's immune response. This research identifies the plant Croton oligandrus as a potent antiviral. Extracts from this plant demonstrated latency-reversing potential and might serve as foundation materials for new HIV/AIDS cures.




    University of Buea

    Chantal EMADE NKWELLE holds a master’s degree in microbiology from the University of Buea, Cameroon. She is currently a PhD student in the same programme and University. She has gone through a 1year class work and a comprehensive examination at the end of the semester (2021-2022). Thereafter, she obtained an HIV drug discovery training at the Wistar Institute of Anatomy and Biology, Philadelphia, USA, in preparation for her PhD. research work. Chantal is currently in the research phase of her PhD. programme. more

  • Dr. Fidele NTIE-KANG

    Dr. Fidele NTIE-KANG

    Dr. Fidele Ntie-Kang is an Associate Professor of Pharmaceutical Chemistry at the Department of Chemistry, University of Buea in Cameroon, where he heads the Center for Drug Discovery. After studying chemistry and physics at the University of Douala in Cameroon, he completed a PhD in computer-aided drug design. He then moved to Germany for postdoctoral research under Prof. Wolfgang Sippl, leading to a habilitation in pharmaceutical chemistry. Since then, his research has been focused on chemoinformatics for natural products research. He holds several editorial board appointments and his major contribution is the development of the African Natural Products Database. more

  • Prof. Roland N. NDIP

    Prof. Roland N. NDIP

    Roland N. NDIP is a Professor of Microbiology and current Dean of the Faculty of Science, University of Buea, Cameroon. Professor NDIP studied at premier institutions in Nigeria (BSc, MSc, PhD in Medical Microbiology) with specializations in pathogenic and molecular microbiology. He extended his training through participation in short courses and laboratory visits abroad at the University of Glasgow, Scotland, and the German Research Centre for Biotechnology, Braunschweig, Germany. Professor NDIP has a long standing interest and active research programme in infectious disease, and in the utility of both western and traditional (herbal) medicines for the treatment of infectious diseases. more

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