BioLogic is the first self-transforming garment that reacts in symbiosis with the human body. The bio-hybrid garment is based on the natural phenomenon of hygromorphic transformation and uses living cells as nanosensors and nanoactuators that are stimulated by body temperature and humidity change. A bio-printing system and design simulation software were developed to simulate the functional transformation and fabrication of the BioLogic’s smart, living materials.